Chirality 2014-12-01

Direct asymmetric anti-Mannich-type reactions catalyzed by cinchona alkaloid derivatives.

Ying Jin, Di Chen, Xiu Rong Zhang

Index: Chirality 26(12) , 801-5, (2014)

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Abstract

A series of cinchona alkaloid derivatives were used to catalyze the asymmetric anti-Mannich-type reaction of 3-methyl-2-oxindole with N-tosyl aryl aldimines. The resulting anti-3,3-disubstituted 2-oxindole products were obtained in good yields (up to 92%) with high diastereo- and enantioselectivities (anti/syn up to 97:3 and 91% ee).© 2014 Wiley Periodicals, Inc.