Human & Experimental Toxicology 2002-03-01

Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs.

E L Berryman, A C Zerouala, C Meschter, J Spenard

Index: Hum. Exp. Toxicol. 21(3) , 159-63, (2002)

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Abstract

Intrarectal administration of 5-aminosalicylic acid (5-ASA) to rabbits and dogs was performed to obtain safety data. Groups of rabbits and dogs received twice daily intrarectal doses of 250, 500 or 1000 mg 5-ASA for 14 consecutive days. Treatment had no adverse effect on the behaviour or performance of the animals and microscopic examination revealed no evidence of systemic or local toxicity.