Biological & Pharmaceutical Bulletin 2006-11-01

Effects of isopropyl palmitate on the skin permeation of drugs.

Hong Guo, Zhidong Liu, Jizhong Li, Shufang Nie, Weisan Pan

Index: Biol. Pharm. Bull. 29(11) , 2324-6, (2006)

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Abstract

The model penetrants oxaprozin, nimesulide, gliclazide, and ribavirin, because of their different lipophilicities, were selected to assess the enhancing activity of pre-treatment solutions consisting of isopropyl palmitate (IP) in ethanol (5%, 10%, 15%and 20%, w/w, respectively) across excised rat skin using Franz diffusion cells and HPLC detection. All pre-treatment solutions produced a significant increase in the flux and permeation of all four penetrants (p<0.001) and a relationship between penetrant lipophilicity and enhancement effect was observed. The general order of IP effectiveness at concentration was 20%>15%>10%>5% (w/w). The lag-time of drugs did not significantly change except for ribavirin.