e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

New anticancer agents: synthesis of 1, 2-dihydropyrido [3, 4-b] pyrazines (1-deaza-7, 8-dihydropteridines)

C Temple Jr, GP Wheeler, RD Elliott…

Index: Temple, Carroll; Wheeler, Glynn P.; Elliott, Robert D.; Rose, Jerry D.; Kussner, Conrad L.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1045 - 1050

Full Text: HTML

Citation Number: 25

Abstract

Reaction of a-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2- carbamate (1) gave ethyl 6-amino-5-nitro-4-[(2-0~ 0-2-phenylethyl) amino] pyridine-2- carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4). Related pyridines substituted with a keto side chain were prepared from 1 and 1, 3-diaminopropanone oximes and by oxidation of the side-chain ...

ethyl N-[6-amino-4-[[(2Z)-2-(4-chlorophenyl)-2-hydroxyimino-ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~59%

Carbamic acid,[6-amino-4-[[2-(4-chlorophenyl)-2-oxoethyl]amino]-5-nitro-2-pyridinyl]-, ethylester (9CI) Structure

Carbamic acid,[...

ethyl (6-amino-4-((2-(2,4-dichlorophenyl)-2-(hydroxyimino)ethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~62%

Carbamic acid, (5-amino-3-(2,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

α-amino-2,4-dichloroacetophenone oxime Structure

α-amino-2,4-dic...

~%

Carbamic acid, (5-amino-3-(2,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

N/A Structure

~%

Carbamic acid, (5-amino-3-(2,4-dichlorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

N/A Structure

~65%

N-[2-amino-1-(2,4-dimethylphenyl)ethylidene]hydroxylamine Structure

N-[2-amino-1-(2...

Carbamic acid,[6-amino-4-[[2-(4-chlorophenyl)-2-oxoethyl]amino]-5-nitro-2-pyridinyl]-, ethylester (9CI) Structure

Carbamic acid,[...

~78%

ethyl N-[5-amino-8-(4-chlorophenyl)-4,7,10-triazabicyclo[4.4.0]deca-1,3,5,7-tetraen-3-yl]carbamate Structure

ethyl N-[5-amin...

ethyl N-[6-amino-4-[[(2Z)-2-(4-chlorophenyl)-2-hydroxyimino-ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~%

ethyl N-[5-amino-8-(4-chlorophenyl)-4,7,10-triazabicyclo[4.4.0]deca-1,3,5,7-tetraen-3-yl]carbamate Structure

ethyl N-[5-amin...

N/A Structure

~%

Carbamic acid,[6-amino-4-[[2-hydroxy-3-[(4-methoxyphenyl)methylamino]propyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

N-Methyl-4-anisidine Structure

N-Methyl-4-anisidine

~%

Carbamic acid,[6-amino-4-[[2-hydroxy-3-[(4-methoxyphenyl)methylamino]propyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

Carbamic acid, [6-amino-4-[[3-[(4-chlorophenyl)methylamino]-2-hydroxypropyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid, ...

~20%

ethyl N-[6-amino-4-[[3-[(4-chlorophenyl)-methyl-amino]-2-oxo-propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

4-Chloro-N-methylaniline Structure

4-Chloro-N-meth...

~%

ethyl N-[6-amino-4-[[3-[(4-chlorophenyl)-methyl-amino]-2-oxo-propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

4-chloro-N-methyl-N-(oxiran-2-ylmethyl)aniline Structure

4-chloro-N-meth...

~%

ethyl N-[6-amino-4-[[3-[(4-chlorophenyl)-methyl-amino]-2-oxo-propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

2-Propanol,1-amino-3-[(4-chlorophenyl)methylamino]- Structure

2-Propanol,1-am...

~%

ethyl N-[6-amino-4-[[3-[(4-chlorophenyl)-methyl-amino]-2-oxo-propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

2-[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

Ethanone,2-amino-1-[4-(trifluoromethyl)phenyl]-, oxime Structure

Ethanone,2-amin...

2-[(2Z)-2-hydroxyimino-3-[(4-methoxyphenyl)-methyl-amino]propyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

Carbamic acid,[6-amino-4-[[2-(hydroxyimino)-3-[(4-methoxyphenyl)methylamino]propyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

Carbamic acid,[6-amino-4-[[2-(hydroxyimino)-3-[(4-methoxyphenyl)methylamino]propyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

~71%

Carbamic acid,[5-amino-1,2-dihydro-3-[[(4-methoxyphenyl)methylamino]methyl]pyrido[3,4-b]pyrazin-7-yl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

(NZ)-N-[1-amino-3-[(4-methoxyphenyl)-methyl-amino]propan-2-ylidene]hydroxylamine Structure

(NZ)-N-[1-amino...

~%

Carbamic acid,[5-amino-1,2-dihydro-3-[[(4-methoxyphenyl)methylamino]methyl]pyrido[3,4-b]pyrazin-7-yl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

2-[(2Z)-2-hydroxyimino-3-[(4-methoxyphenyl)-methyl-amino]propyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

Carbamic acid,[5-amino-1,2-dihydro-3-[[(4-methoxyphenyl)methylamino]methyl]pyrido[3,4-b]pyrazin-7-yl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

2-[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

ethyl N-[6-amino-4-[[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

Carbamic acid,[6-amino-4-[[2-(hydroxyimino)-2-(4-methoxyphenyl)ethyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

~53%

Carbamic acid,[6-amino-4-[[2-(4-methoxyphenyl)-2-oxoethyl]amino]-5-nitro-2-pyridinyl]-, ethylester (9CI) Structure

Carbamic acid,[...

N/A Structure

~%

Carbamic acid,[6-amino-4-[[2-(4-methoxyphenyl)-2-oxoethyl]amino]-5-nitro-2-pyridinyl]-, ethylester (9CI) Structure

Carbamic acid,[...

Ethanone, 2-chloro-1-(3-methoxyphenyl)- (9CI) Structure

Ethanone, 2-chl...

Potassium phthalimide Structure

Potassium phtha...

~%

2-[2-(3-methoxyphenyl)-2-oxoethyl]isoindole-1,3-dione Structure

2-[2-(3-methoxy...

4-Chloro-N-methylaniline Structure

4-Chloro-N-meth...

Epichlorohydrin Structure

Epichlorohydrin

~72%

4-chloro-N-methyl-N-(oxiran-2-ylmethyl)aniline Structure

4-chloro-N-meth...

2-(2-(hydroxyimino)-2-(3-methoxyphenyl)ethyl)isoindoline-1,3-dione Structure

2-(2-(hydroxyim...

~%

2-AMINO-1-(3-METHOXY-PHENYL)-ETHANONE OXIME Structure

2-AMINO-1-(3-ME...

1-phthalimido-3-bromopropan-2-one Structure

1-phthalimido-3...

N-Methyl-4-anisidine Structure

N-Methyl-4-anisidine

~%

2-[3-[(4-methoxyphenyl)-methyl-amino]-2-oxo-propyl]isoindole-1,3-dione Structure

2-[3-[(4-methox...

4-Chloro-N-methylaniline Structure

4-Chloro-N-meth...

~%

Carbamic acid, [6-amino-4-[[3-[(4-chlorophenyl)methylamino]-2-hydroxypropyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid, ...

4-chloro-N-methyl-N-(oxiran-2-ylmethyl)aniline Structure

4-chloro-N-meth...

~%

Carbamic acid, [6-amino-4-[[3-[(4-chlorophenyl)methylamino]-2-hydroxypropyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid, ...

ethyl N-[6-amino-4-[[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~30%

ethyl N-[6-amino-5-nitro-4-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]amino]pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

Ethanone,2-amino-1-[4-(trifluoromethyl)phenyl]-, oxime Structure

Ethanone,2-amin...

~%

ethyl N-[6-amino-5-nitro-4-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]amino]pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

2-[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

ethyl N-[6-amino-5-nitro-4-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]amino]pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

ethyl (6-amino-5-nitro-4-((2-oxo-2-(3,4,5-trimethoxyphenyl)ethyl)amino)pyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~70%

Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3 ,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

2-amino-1-(3,4,5-trimethoxyphenyl)ethan-1-one oxime Structure

2-amino-1-(3,4,...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3 ,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

2-(2-(hydroxyimino)-2-(3,4,5-trimethoxyphenyl)ethyl)isoindoline-1,3-dione Structure

2-(2-(hydroxyim...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3 ,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl (6-amino-4-((2-(hydroxyimino)-2-(3,4,5-trimethoxyphenyl)ethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(3,4,5-trimethoxyphenyl)pyrido(3 ,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl (6-amino-5-nitro-4-((2-(4-nitrophenyl)-2-oxoethyl)amino)pyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~17%

Carbamic acid, (5-amino-3-(4-aminophenyl)-1,2-dihydropyrido(3,4-b)pyra zin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl N-[6-amino-4-[[(2Z)-2-hydroxyimino-2-(4-nitrophenyl)ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~%

Carbamic acid, (5-amino-3-(4-aminophenyl)-1,2-dihydropyrido(3,4-b)pyra zin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

(NE)-N-[2-amino-1-(4-nitrophenyl)ethylidene]hydroxylamine Structure

(NE)-N-[2-amino...

~%

Carbamic acid, (5-amino-3-(4-aminophenyl)-1,2-dihydropyrido(3,4-b)pyra zin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

N/A Structure

~%

2-amino-1-p-tolyl-ethanone oxime Structure

2-amino-1-p-tol...

ethyl (6-amino-4-((2-(3,4-dimethylphenyl)-2-oxoethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~85%

Carbamic acid,[5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]-, ethylester (9CI) Structure

Carbamic acid,[...

2-(2-(3,4-dimethylphenyl)-2-(hydroxyimino)ethyl)isoindoline-1,3-dione Structure

2-(2-(3,4-dimet...

~%

Carbamic acid,[5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]-, ethylester (9CI) Structure

Carbamic acid,[...

ethyl (6-amino-4-((2-(3,4-dimethylphenyl)-2-(hydroxyimino)ethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~%

Carbamic acid,[5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]-, ethylester (9CI) Structure

Carbamic acid,[...

2-amino-1-(3,4-dimethylphenyl)ethan-1-one oxime Structure

2-amino-1-(3,4-...

~%

Carbamic acid,[5-amino-3-(3,4-dimethylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]-, ethylester (9CI) Structure

Carbamic acid,[...

2-Oxiranemethanamine,N-methyl-N-phenyl- Structure

2-Oxiranemethan...

~%

ethyl N-[6-amino-4-[[2-hydroxy-3-(methyl-phenyl-amino)propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

N-Methylaniline Structure

N-Methylaniline

~%

ethyl N-[6-amino-4-[[2-hydroxy-3-(methyl-phenyl-amino)propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

2-Oxiranemethanamine,N-methyl-N-phenyl- Structure

2-Oxiranemethan...

~%

2-Propanol,1-amino-3-(methylphenylamino)- Structure

2-Propanol,1-am...

N-Methylaniline Structure

N-Methylaniline

~%

2-Propanol,1-amino-3-(methylphenylamino)- Structure

2-Propanol,1-am...

N-Methylaniline Structure

N-Methylaniline

Epichlorohydrin Structure

Epichlorohydrin

~%

2-Oxiranemethanamine,N-methyl-N-phenyl- Structure

2-Oxiranemethan...

ethyl N-[6-amino-5-nitro-4-[[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]amino]pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~57%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

Ethanone,2-amino-1-[4-(trifluoromethyl)phenyl]-, oxime Structure

Ethanone,2-amin...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

2-[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl N-[6-amino-4-[[(2Z)-2-hydroxyimino-2-[4-(trifluoromethyl)phenyl]ethyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-(trifluoromethyl)phenyl)pyrid o(3,4-b)pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl (4-((2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)amino)-6-amino-5-nitropyridin-2-yl)carbamate Structure

ethyl (4-((2-([...

~84%

ethyl N-[5-amino-3-(4-phenylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

ethyl (4-((2-([1,1'-biphenyl]-4-yl)-2-(hydroxyimino)ethyl)amino)-6-amino-5-nitropyridin-2-yl)carbamate Structure

ethyl (4-((2-([...

~%

ethyl N-[5-amino-3-(4-phenylphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

ethyl (6-amino-5-nitro-4-((2-oxo-2-phenylethyl)amino)pyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~91%

Carbamic acid, (5-amino-1,2-dihydro-3-phenylpyrido[3, 4-b]pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

Ethanone,2-amino-1-phenyl-,oxime Structure

Ethanone,2-amin...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-phenylpyrido[3, 4-b]pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

Carbamic acid, [6-amino-4-[[2-(hydroxyimino)-2-phenylethyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid, ...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-phenylpyrido[3, 4-b]pyrazin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl (6-amino-4-((2-(2,4-dimethylphenyl)-2-(hydroxyimino)ethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~84%

Ethyl (5-amino-3-(2,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

N-[2-amino-1-(2,4-dimethylphenyl)ethylidene]hydroxylamine Structure

N-[2-amino-1-(2...

~%

Ethyl (5-amino-3-(2,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

N/A Structure

~%

Ethyl (5-amino-3-(2,4-dimethylphenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

ethyl 6-amino-4-[[3-(N-methyl-N-phenylamino)-2-oxopropyl]amino]-5-nitro-2-pyridinecarbamate oxime Structure

ethyl 6-amino-4...

~63%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

ethyl 6-amino-4-[[3-(N-methyl-N-phenylamino)-2-oxopropyl]amino]-5-nitro-2-pyridinecarbamate Structure

ethyl 6-amino-4...

~32%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

2-Oxiranemethanamine,N-methyl-N-phenyl- Structure

2-Oxiranemethan...

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

2-Propanol,1-amino-3-(methylphenylamino)- Structure

2-Propanol,1-am...

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

1-amino-3-(N-methyl-N-phenylamino)propanone oxime Structure

1-amino-3-(N-me...

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

N/A Structure

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

ethyl N-[6-amino-4-[[2-hydroxy-3-(methyl-phenyl-amino)propyl]amino]-5-nitro-pyridin-2-yl]carbamate Structure

ethyl N-[6-amin...

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

N-Methylaniline Structure

N-Methylaniline

~%

ethyl N-[5-amino-3-[(N-methylanilino)methyl]-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate Structure

ethyl N-[5-amin...

Carbamic acid,[6-amino-4-[[2-(4-methoxyphenyl)-2-oxoethyl]amino]-5-nitro-2-pyridinyl]-, ethylester (9CI) Structure

Carbamic acid,[...

~71%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-methoxyphenyl)pyrido(3,4-b)py razin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

N/A Structure

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-methoxyphenyl)pyrido(3,4-b)py razin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

Carbamic acid,[6-amino-4-[[2-(hydroxyimino)-2-(4-methoxyphenyl)ethyl]amino]-5-nitro-2-pyridinyl]-,ethyl ester (9CI) Structure

Carbamic acid,[...

~%

Carbamic acid, (5-amino-1,2-dihydro-3-(4-methoxyphenyl)pyrido(3,4-b)py razin-7-yl)-, ethyl ester Structure

Carbamic acid, ...

ethyl (6-amino-4-((2-(4-fluorophenyl)-2-oxoethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~79%

Ethyl (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE OXIME Structure

2-AMINO-1-(4-FL...

~%

Ethyl (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

N/A Structure

~%

Ethyl (5-amino-3-(4-fluorophenyl)-1,2-dihydropyrido(3,4-b)pyrazin-7-yl)carbamate Structure

Ethyl (5-amino-...

2-[(2Z)-2-hydroxyimino-3-[(4-methoxyphenyl)-methyl-amino]propyl]isoindole-1,3-dione Structure

2-[(2Z)-2-hydro...

~%

(NZ)-N-[1-amino-3-[(4-methoxyphenyl)-methyl-amino]propan-2-ylidene]hydroxylamine Structure

(NZ)-N-[1-amino...

Potassium phthalimide Structure

Potassium phtha...

Ethanone, 2-chloro-1-[4-(trifluoromethyl)phenyl]- Structure

Ethanone, 2-chl...

~%

2-[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]isoindole-1,3-dione Structure

2-[2-oxo-2-[4-(...

ethyl (6-amino-5-nitro-4-((2-oxo-2-(p-tolyl)ethyl)amino)pyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~85%

CI 980 Structure

N/A Structure

~%

CI 980 Structure

2-amino-1-p-tolyl-ethanone oxime Structure

2-amino-1-p-tol...

~%

CI 980 Structure

ethyl (6-amino-4-((2-(hydroxyimino)-2-(p-tolyl)ethyl)amino)-5-nitropyridin-2-yl)carbamate Structure

ethyl (6-amino-...

~%

CI 980 Structure

4-chloro-N-methyl-N-(oxiran-2-ylmethyl)aniline Structure

4-chloro-N-meth...

~45%

2-Propanol,1-amino-3-[(4-chlorophenyl)methylamino]- Structure

2-Propanol,1-am...

4-Chloro-N-methylaniline Structure

4-Chloro-N-meth...

~%

2-Propanol,1-amino-3-[(4-chlorophenyl)methylamino]- Structure

2-Propanol,1-am...