Mutation Research/Genetic Toxicology and Environmental Mutagenesis 1993-01-01

Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test

Satoru Itoh, Miyuki Igarashi, Mayumi Nagata, Chiharu Hattori

Index: Mutat. Res. Genet. Toxicol. Environ. Mutagen. 782 , 18-23, (2015)

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Abstract

• Effectiveness of twice dosing regimen was evaluated in the rat liver MN test. • Results from twice dosing regimen are similar to those from single dosing regimens. • Twice dosing regimen could detect clastogenic and aneugenic activity simultaneously.