Bioorganic & Medicinal Chemistry Letters 2011-05-15

Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins.

Pardeep Singh, Sharanjeet Kaur, Vipan Kumar, P M S Bedi, M P Mahajan, Irum Sehar, Harish Chandra Pal, Ajit Kumar Saxena

Index: Bioorg. Med. Chem. Lett. 21 , 3017-20, (2011)

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Abstract

The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 μM concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 μM against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively.Copyright © 2011 Elsevier Ltd. All rights reserved.