Tetrahedron Letters

Metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into aromatic amides with molecular iodine in aq ammonia, and hydrogen peroxide

R Ohmura, M Takahata, H Togo

Index: Ohmura, Ryosuke; Takahata, Misato; Togo, Hideo Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4378 - 4381

Full Text: HTML

Citation Number: 30

Abstract

Various primary alcohols, particularly benzylic alcohols, could be converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq. NH3, followed by reaction with∼ 30% aq H2O2. Similarly, various benzylic halides could be also converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq NH3, followed by ...

 Related Synthetic Route

~67%

Learn More

~68%

Learn More

~64%

Learn More

~86%

Learn More

~81%

Learn More

~73%

Learn More

~72%

Learn More

~86%

Learn More

~92%

Learn More

~73%

Learn More

~90%

Learn More

~96%

Learn More

~99%

Learn More

~90%

Learn More

~87%

Learn More

~93%

Learn More

~63%

Learn More

~85%

Learn More

~92%

Learn More

~81%

Learn More

~66%

Learn More

~71%

Learn More