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Tetrahedron Letters

Metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into aromatic amides with molecular iodine in aq ammonia, and hydrogen peroxide

R Ohmura, M Takahata, H Togo

文献索引:Ohmura, Ryosuke; Takahata, Misato; Togo, Hideo Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4378 - 4381

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被引用次数: 30

摘要

Various primary alcohols, particularly benzylic alcohols, could be converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq. NH3, followed by reaction with∼ 30% aq H2O2. Similarly, various benzylic halides could be also converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq NH3, followed by ...