Journal of Peptide Science 1999-08-01

Im-trityl protection of histidine.

S J Harding, J H Jones, A N Sabirov, V V Samukov

Index: J. Pept. Sci. 5(8) , 368-73, (1999)

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Abstract

A rational attempt to prepare FmocHis(piTrt)OH regiospecifically gave in fact the well-known tau-trityl isomer, and experiments with model systems indicate that the prospects for access to pi-trityl histidine derivatives, which would be of great value for the racemization-free synthesis of histidine-containing peptides, are poor.