Journal of Organic Chemistry 2012-08-17

Method for activation and recycling of trityl resins.

Itedale Namro Redwan, Morten Grøtli

Index: J. Org. Chem. 77(16) , 7071-5, (2012)

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Abstract

This note describes a rapid and mild strategy for the loading of alcohols and anilines onto a polystyrene triphenylmethyl (trityl) resin. High loadings were obtained in a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate followed by alcohols or anilines. Yields were comparable or better than known literature methods. Recycling of the recovered resin was also possible using the developed method.