Chemistry: A European Journal 2012-11-05

Transition-metal-free atropo-selective synthesis of biaryl compounds based on arynes.

Frédéric R Leroux, Anaïs Berthelot, Laurence Bonnafoux, Armen Panossian, Françoise Colobert

Index: Chemistry 18(45) , 14232-6, (2012)

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Abstract

A modular way towards biaryls: Highly enantioenriched biphenyls can be prepared based on a transition-metal-free aryl-aryl coupling followed by efficient desymmetrization or deracemization and chemoselective functionalization (see scheme).Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.