JAIDS Journal of Acquired Immune Deficiency Syndromes 2013-06-01

Nevirapine inhibits the anti-HIV activity of CD8+ cells.

Lianxing Liu, Lin Wang, Liusheng Huang, Vincent Siu, Fernando Teque, Francesca T Aweeka, Jay A Levy

Index: J. Acquir. Immune Defic. Syndr. 63(2) , 184-8, (2013)

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Abstract

Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8(+) cells and thus could influence the effectiveness of antiretroviral therapy.