Food and Chemical Toxicology 2014-06-01

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Yu Fen Zheng, Soo Hyeon Bae, Eu Jin Choi, Jung Bae Park, Sun Ok Kim, Min Jung Jang, Gyu Hwan Park, Wan Gyoon Shin, Euichaul Oh, Soo Kyung Bae

Index: Food Chem. Toxicol. 68 , 117-27, (2014)

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Abstract

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacokinetics of drugs metabolized by CYPs/UGTs.