China Journal of Chinese Materia Medica 2012-05-01

[Non-alkaloid chemical constituents from Coptis chinensis].

Liang Chen, Lei Wang, Qingwen Zhang, Shengyuan Zhang, Wencai Ye

Index: Zhongguo Zhong Yao Za Zhi 37(9) , 1241-4, (2012)

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Abstract

To separate and identify chemical constituents from Coptis chinensis.The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of their physicochemical properties using spectral techniques such as NMR and MS.Thirteen compounds were separated from ethanol extracts of C. chinensis, including seven lignans, three simple phenylpropanoids, two flavones and one phenolic acid, and identified as erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), (+)-pinoresinol (3), (+)-medioresinol (4), (+)-lariciresinol (5), (+)-5'-methoxylariciresinol (6), (+)-isolariciresinol (7), chlorogenic acid (8), ferulic acid (9), Z-octadecyl caffeate (10), rhamnetin (11), wogonin (12), and vanillic acid (13).Compounds 1, 2, 4, 6, 10-13 were separated from the genus Coptis for the first time.