Bioorganic & Medicinal Chemistry Letters 2010-09-01

InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives.

Neelakandan Vidhya Lakshmi, Prakasam Thirumurugan, K M Noorulla, Paramasivan T Perumal

Index: Bioorg. Med. Chem. Lett. 20 , 5054-61, (2010)

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Abstract

A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl(3) in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug.Copyright 2010 Elsevier Ltd. All rights reserved.