Toxicology Letters 2011-07-28

Stress responses of human dermal fibroblasts exposed to zinc pyrithione

Emil Rudolf, Miroslav Cervinka

Index: Toxicol. Lett. 204(2-3) , 164-73, (2011)

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Abstract

Highlights ► Zinc pyrithione (ZnPyr) is cytotoxic in human dermal fibroblasts. ► High ZnPyr induces p53- and p38-dependent response and mitochondrial apoptosis. ► Low ZnPyr induces weak stress response without affecting mitogenic signaling. ► Low ZnPyr stimulates premature senescence in dermal fibroblasts.