International Journal of Pharmaceutics 2014-08-25

Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.

Maria Grazia Sarpietro, Maria Lorena Accolla, Giovanni Puglisi, Francesco Castelli, Lucia Montenegro

Index: Int. J. Pharm. 471(1-2) , 69-74, (2014)

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Abstract

In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with different amount of idebenone (IDE), an antioxidant drug useful in the treatment of neurodegenerative diseases and skin oxidative damages. The differential scanning calorimetry (DSC) was employed to evaluate the effects of the different emulsifiers and the different amounts of drug loaded on the thermotropic behavior of SLN and to investigate how the drug was arranged into these nanoparticles. The IDE seemed to be located into different regions of the SLN depending on its concentration and on the surfactant used. The results of this study suggest that the calorimetric studies performed on SLN could provide valuable information to optimize SLN design and drug release from these carriers. Copyright © 2014 Elsevier B.V. All rights reserved.