Journal of Chromatography A 2014-10-31

Optimization of a preparative multimodal ion exchange step for purification of a potential malaria vaccine

Jessica Paul, Sonja Jensen, Arthur Dukart, Gesine Cornelissen

Index: J. Chromatogr. A. 1366 , 38-44, (2014)

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Abstract

• The critical process parameters could be identified and quantified. • The binding of the target product was exclusively in hydrophobic interaction mode. • A product recovery of 61% and purity PP1e2C of 60% can be achieved. • The model created is suitable for the prediction of future experiments.