Journal of Fluorine Chemistry

Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate

BR Langlois, N Roques

Index: Langlois, Bernard R.; Roques, Nicolas Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1318 - 1325

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Citation Number: 60

Abstract

When associated with an alkaline halide, such as cesium fluoride or cesium chloride, and Cu (I) species, methyl trifluoroacetate (MTFA) constitutes a valuable trifluoromethylating agent for substituting aromatic (or heteroaromatic) iodides and bromides. The reaction can be carried out in DMF at 180° C or, better, in sulfolane which allows he reaction to proceed at a lower temperature (from 140° C).

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