International Journal of Nanomedicine 2015-01-01

Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans.

Akhtar Nadhman, Samina Nazir, Malik Ihsanullah Khan, Attiya Ayub, Bakhtiar Muhammad, Momin Khan, Dilawar Farhan Shams, Masoom Yasinzai

Index: Int. J. Nanomedicine 10 , 6891-903, (2015)

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Abstract

Human beings suffer from several infectious agents such as viruses, bacteria, and protozoans. Recently, there has been a great interest in developing biocompatible nanostructures to deal with infectious agents. This study investigated benign ZnCuO nanostructures that were visible-light-responsive due to the resident copper in the lattice. The nanostructures were synthesized through a size-controlled hot-injection process, which was adaptable to the surface ligation processes. The nanostructures were then characterized through transmission electron microscopy, X-ray diffraction, diffused reflectance spectroscopy, Rutherford backscattering, and photoluminescence analysis to measure crystallite nature, size, luminescence, composition, and band-gap analyses. Antiprotozoal efficiency of the current nanoparticles revealed the photodynamic killing of Leishmania protozoan, thus acting as efficient metal-based photosensitizers. The crystalline nanoparticles showed good biocompatibility when tested for macrophage toxicity and in hemolysis assays. The study opens a wide avenue for using toxic material in resident nontoxic forms as an effective antiprotozoal treatment.