Tetrahedron

Palladium-catalyzed coupling reaction of amino acids (esters) with aryl bromides and chlorides

F Ma, X Xie, L Ding, J Gao, Z Zhang

Index: Ma, Fangfang; Xie, Xiaomin; Ding, Lina; Gao, Jinsheng; Zhang, Zhaoguo Tetrahedron, 2011 , vol. 67, # 48 p. 9405 - 9410

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Citation Number: 11

Abstract

The bulky and electron-rich MOP type ligands and Pd (dba) 2 combinations showed high efficiency for the coupling reactions of amino acids and inactive aryl halides to give N-aryl amino acids. Under the catalytic conditions, not only α-amino acids, but also β-, γ-, and δ- amino acids have been coupled with aryl chlorides in moderate to high yields; in the case of optically pure β-amino acids as substrates, the optical purities of the coupling products ...