Chemico-Biological Interactions 2015-05-25

Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor

Eun Ji Joo, Jaemoo Chun, Young Wan Ha, Hye Jin Ko, Mei-Ying Xu, Yeong Shik Kim

Index: Chem. Biol. Interact. 233 , 25-34, (2015)

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Abstract

• Ginsenoside Rg3 induces apoptosis with strong cytotoxicity. • Ginsenoside Rg3 modulates EGFR internalization. • Ginsenoside Rg3 induces EGFR degradation after internalization. • Ginsenoside Rg3 inhibits tumor growth in LLC-bearing C57BL/6 mice.