Hydroperoxylation by hydroxyethylphosphonate dioxygenase

JT Whitteck, RM Cicchillo, WA Donk

Index: Whitteck, John T.; Cicchillo, Robert M.; Van Der Donk, Wilfred A. Journal of the American Chemical Society, 2009 , vol. 131, # 44 p. 16225 - 16232

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Citation Number: 32

Abstract

Hydroxyethylphosphonate dioxygenase (HEPD) catalyzes the O2-dependent cleavage of the carbon− carbon bond of 2-hydroxyethylphosphonate (2-HEP) to afford hydroxymethylphosphonate (HMP) and formate without input of electrons or use of any organic cofactors. Two mechanisms have been proposed to account for this reaction. One involves initial hydroxylation of substrate to an acetal intermediate and its subsequent ...