Hydroperoxylation by hydroxyethylphosphonate dioxygenase

JT Whitteck, RM Cicchillo, WA Donk

文献索引：Whitteck, John T.; Cicchillo, Robert M.; Van Der Donk, Wilfred A. Journal of the American Chemical Society, 2009 , vol. 131, # 44 p. 16225 - 16232

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被引用次数: 32

摘要

Hydroxyethylphosphonate dioxygenase (HEPD) catalyzes the O2-dependent cleavage of the carbon− carbon bond of 2-hydroxyethylphosphonate (2-HEP) to afford hydroxymethylphosphonate (HMP) and formate without input of electrons or use of any organic cofactors. Two mechanisms have been proposed to account for this reaction. One involves initial hydroxylation of substrate to an acetal intermediate and its subsequent ...