Peptide synthesis in aqueous solution. I. Application of p-dialkylsulfoniophenols as a water-soluble coupling reagent

K Kouge, T Koizumi, H Okai, T Kato

Index: Kouge; Koizumi; Okai; Kato Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418

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Citation Number: 57

Abstract

(p-Hydroxyphenyl) dimethylsulfonium methyl sulfate (HODMSP· MeSO 4−) was found to be an excellent coupling reagent having a water-soluble property and a high reactivity; it worked as satisfactory as usual active esters in regard to the reactivity, product purity, and racemization. The marked advantage of the HODMSP· MeSO 4− active ester method was the fact that bifunctional residues such as Arg, Lys, Cys, and Tyr could be selectively ...