The Journal of Steroid Biochemistry and Molecular Biology 2014-10-01

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro

Steven Pham, Subrata Deb, Dong Sheng Ming, Hans Adomat, Elham Hosseini-Beheshti, Amina Zoubeidi, Martin Gleave, Emma S.Tomlinson Guns

Index: J. Steroid Biochem. Mol. Biol. 144 Pt B , 436-44, (2014)

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Abstract

• Dutasteride and abiraterone were evaluated for inhibition of steroidogenesis. • Bypass mechanisms arise in the presence of abiraterone to form DHT. • Dutasteride inhibits T and DHT effectively in vitro. • Abiraterone inhibits AR and steroidogenesis leading to suppression of PSA. • Combining abiraterone and dutasteride activate compensatory mechanisms.