Synthesis and biological activities of aldose reductase inhibitors bearing acyl benzenesulfonamides as carboxylic acid surrogates

…, PF Kador, T Mizoguchi, A Bartoszko-Malik…

Index: Donkor, Isaac O.; Abdel-Ghany, Yasser S.; Kador, Peter F.; Mizoguchi, Tadashi; Bartoszko-Malik, Anita; Miller, Duane D. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 15 - 22

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Citation Number: 12

Abstract

We have synthesized alrestatin derivatives 1–11 possessing acyl benzenesulfonamide groups as surrogates for the carboxylic acid moiety of alrestatin. Most of the compounds were inactive as aldose reductase inhibitors compared to alrestatin, however, some of them demonstrated selectivity towards inhibition of rat kidney aldehyde reductase compared to rat lens aldose reductase suggesting that structural differences may exist between the ...