Advanced Synthesis & Catalysis

Asymmetric Epoxidation of α, β??Unsaturated Aldehydes in Aqueous Media Catalyzed by Resin??Supported Peptide??Containing Unnatural Amino Acids

K Akagawa, K Kudo

Index: Akagawa, Kengo; Kudo, Kazuaki Advanced Synthesis and Catalysis, 2011 , vol. 353, # 6 p. 843 - 847

Full Text: HTML

Citation Number: 28

Abstract

Abstract The enantio-and diastereoselective epoxidation of α, β-unsaturated aldehydes in aqueous media was realized using a resin-supported peptide catalyst. Introducing the hydrophobic and bulky unnatural amino acid 3-(1-pyrenyl) alanine into the peptide sequence was effective for enhancing the reaction rate and enantioselectivity.