Advanced Synthesis & Catalysis

Asymmetric Epoxidation of α, β??Unsaturated Aldehydes in Aqueous Media Catalyzed by Resin??Supported Peptide??Containing Unnatural Amino Acids

K Akagawa, K Kudo

文献索引：Akagawa, Kengo; Kudo, Kazuaki Advanced Synthesis and Catalysis, 2011 , vol. 353, # 6 p. 843 - 847

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被引用次数: 28

摘要

Abstract The enantio-and diastereoselective epoxidation of α, β-unsaturated aldehydes in aqueous media was realized using a resin-supported peptide catalyst. Introducing the hydrophobic and bulky unnatural amino acid 3-(1-pyrenyl) alanine into the peptide sequence was effective for enhancing the reaction rate and enantioselectivity.