Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization

…, JM Klunder, RM Hanson, H Masamune…

Index: Gao, Yun; Hanson, Robert M.; Klunder, Janice M.; Ko, Soo Y.; Masamune, Hiroko; Sharpless, K. Barry Journal of the American Chemical Society, 1987 , vol. 109, # 19 p. 5765 - 5780

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Citation Number: 2017

Abstract

Abstract: The use of 3A or 4A molecular sieves (zeolites) substantially increases the scope of the titanium (1V)-catalyzed asymmetric epoxidation of primary allylic alcohols. Whereas without molecular sieves epoxidations employing only 5 to 10 mol% Ti (Oi-Pr) 4 generally lead to low conversion or low enantioselectivity, in the presence of molecular sieves such reactions generally lead to high conversion (> 95%) and high enantioselectivity (90-95% ...