Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors

L Navidpour, M Amini, H Shafaroodi, K Abdi…

Index: Navidpour, Latifeh; Amini, Mohsen; Shafaroodi, Hamed; Abdi, Khosrou; Ghahremani, Mohammad H.; Dehpour, Ahmad Reza; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4483 - 4487

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Citation Number: 29

Abstract

In an attempt to prepare a new water-soluble, parenteral COX-2 inhibitor, rofecoxib (9) and celecoxib (13) analogues were designed and synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors with in vivo anti-inflammatory activity. In this experiment, respective SO2Me and SO2NH2 hydrogen-bonding pharmacophores were replaced by a tetrazole ring. Molecular modeling (docking) studies showed that the ...