Stereocontrol in Palladium??Catalyzed Propargylic Substitutions: Kinetic Resolution to give Enantioenriched 1, 5??Enynes and Propargyl Acetates

MJ Ardolino, MS Eno, JP Morken

Index: Ardolino, Michael J.; Eno, Meredith S.; Morken, James P. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3413 - 3419

Full Text: HTML

Citation Number: 8

Abstract

Abstract: Kinetic resolution during the catalytic allyl-propargyl cross-coupling with chiral starting materials can be accomplished with a chiral palladium catalyst. These reactions offer ready access to enantiomerically enriched enyne products from simple, readily available starting materials. Keywords: allylation; asymmetric catalysis; asymmetric synthesis; boron; palladium