Tetrahedron

Commercially available neat organozincs as highly reactive reagents for catalytic enantioselective addition to ketones and aldehydes under solvent free conditions

M Hatano, T Mizuno, K Ishihara

Index: Hatano, Manabu; Mizuno, Tomokazu; Ishihara, Kazuaki Tetrahedron, 2011 , vol. 67, # 24 p. 4417 - 4424

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Citation Number: 28

Abstract

Neat Et2Zn, Ph2Zn, and highly concentrated Me2Zn are highly reactive organozinc reagents, which are commercially available in bulk quantities. We here report a catalytic enantioselective Et2Zn, Ph2Zn, and Me2Zn addition to ketones and aldehydes under solvent free or highly concentrated conditions without Ti (Oi-Pr) 4 as a conventional activator of organozinc reagents. The desired optically active tertiary and secondary alcohols were ...