Tetrahedron: Asymmetry

Catalytic enantioselective addition of organoaluminum reagents to aldehydes

E Fernández-Mateos, B Maciá, M Yus

Index: Fernandez-Mateos, Emilio; MacIa, Beatriz; Yus, Miguel Tetrahedron Asymmetry, 2012 , vol. 23, # 10 p. 789 - 794

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Citation Number: 14

Abstract

An efficient catalyst for the asymmetric addition of organoaluminum reagents to aldehydes is presented. The system is based on a readily available binaphthyl derivative as a chiral ligand and an excess of titanium tetraisopropoxide. The asymmetric methylation, ethylation, and propylation of a wide variety of aromatic and aliphatic aldehydes proceeded with good yields and with high enantioselectivities in a simple one-pot procedure under mild ...