Tetrahedron

Commercially available neat organozincs as highly reactive reagents for catalytic enantioselective addition to ketones and aldehydes under solvent free conditions

M Hatano, T Mizuno, K Ishihara

文献索引：Hatano, Manabu; Mizuno, Tomokazu; Ishihara, Kazuaki Tetrahedron, 2011 , vol. 67, # 24 p. 4417 - 4424

全文：HTML全文

被引用次数: 28

摘要

Neat Et2Zn, Ph2Zn, and highly concentrated Me2Zn are highly reactive organozinc reagents, which are commercially available in bulk quantities. We here report a catalytic enantioselective Et2Zn, Ph2Zn, and Me2Zn addition to ketones and aldehydes under solvent free or highly concentrated conditions without Ti (Oi-Pr) 4 as a conventional activator of organozinc reagents. The desired optically active tertiary and secondary alcohols were ...