A simple synthesis of highly functionalized 2, 5-diaminofurans based pyrimidine derivatives from 1-(carboxymethyl) uracil via a multi-component reaction is described. The reactive 1: 1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 1-(carboxymethyl) uracil derivatives to yield polyfunctionalized furan rings in fairly good yields.
