Reactions of Grignard Reagents with Bis-or Mono-Phosphonium lons in Situ Generated from Bu3P and Dicarboxylic Acid Dichlorides or. OMEGA.-Ethoxycarbonyl …

H Maeda, N Hino, Y Yamauchi, H Ohmori

Index: Maeda; Hino; Yamauchi; Ohmori Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 8 p. 1196 - 1199

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Citation Number: 13

Abstract

Reactions of Grignard reagents with bis-phosphonium or mono-phosphonium ions in situ generated from Bu 3 P and ClCO (CH 2) n COCl (5) or ClCO (CH 2) n CO 2 Et (13) as a tool for preparation of symmetrical diketones or ketoesters were examined. Addition of Bu 3 P (2.0 eq) to a THF solution of 5 (n= 2) at-40° C followed by addition of n-BuMgCl (2.0 eq) gave the corresponding diketone in good yield. When a mixture of Bu 3 P and the ...