The Synthesis of an Analog of Chloramphenicol1

WT Caldwell, GC Schweiker

Index: Caldwell; Schweiker Journal of the American Chemical Society, 1953 , vol. 75, p. 5884,5886

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Citation Number: 4

Abstract

A method for the synthesis of the antibiotic, chloramphenicol, has been modified and extended to the preparation of a compound containing a trifluoromethyl group, instead of a nitro group, in the para position of the phenyl ring. An epimerization encountered during one of the alternate preparations of this compound, tkreo-2-dichloroacetamido-1-~- trifluoromethyl-phenyl-1, 3-propanediol (IX), relates it, and several others prepared here, ...