Abstract The reactions of ethyl (5-carbamoyl-3 H-imidazol-4-yl) dithiocarbamate with phenacyl bromides afford the S-alkylation products as a mixture of E/Z-isomers, which undergo cyclization to 5-(2-oxo-4-arylthiazol-3-yl)-1 H-imidazole-4-carboxamides under the action of a base.
![1-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-2-oxo-ethyl]disulfanyl-ethanone Structure](https://image.chemsrc.com/caspic/468/5409-94-9.png)