Tetrahedron Letters

Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles

T Ponpandian, S Muthusubramanian

Index: Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252

Full Text: HTML

Citation Number: 25

Abstract

The efficient synthesis of 2-arylindoles and 6H-isoindolo [2, 1-a] indol-6-one through copper catalysed domino sp-sp2 decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo [1, 2-c] quinazolin-6 (5H)-one can be obtained with the elimination of trifluoromethyl anion.

 Related Synthetic Route

~80%

Learn More

~%

Learn More

~73%

Learn More

~%

Learn More

~78%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~87%

Learn More

~%

Learn More

~72%

Learn More

~88%

Learn More

~50%

Learn More

~86%

Learn More

~%

Learn More

~85%

Learn More

~%

Learn More

~77%

Learn More

~%

Learn More