Tetrahedron Letters

Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles

T Ponpandian, S Muthusubramanian

Index: Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252

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Citation Number: 25

Abstract

The efficient synthesis of 2-arylindoles and 6H-isoindolo [2, 1-a] indol-6-one through copper catalysed domino sp-sp2 decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo [1, 2-c] quinazolin-6 (5H)-one can be obtained with the elimination of trifluoromethyl anion.

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