A Synthesis for unsymmetrically substituted succinic acids

PAS Smith, JP Horwitz

Index: Smith; Horwitz Journal of the American Chemical Society, 1949 , vol. 71, p. 3418

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Citation Number: 11

Abstract

A convenient and somewhat general procedure which we have developed for the synthesis of succinic acids of the type HOOC-CR2-CHz-COOH is described here as applied to seven examples. The procedure, which consists of two laboratory steps, takes place according to the equations (a) R&= O f NC-CH2-COOC2Hs ____f CsHsN. HOAc (b) I f KCN+