Steroids

Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer

M Wang, M Gao, KD Miller, GW Sledge, GD Hutchins…

Index: Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang Steroids, 2010 , vol. 75, # 12 p. 967 - 973

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Citation Number: 2

Abstract

Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer.[11C] casimiroin (6-[11C] methoxy-9-methyl-[1, 3] dioxolo [4, 5-h] quinolin-8 (9H)-one,[11C] 11) and its carbon-11-labeled analogues 5, 6, 8-trimethoxy-1-[11C] methyl-4- methylquinolin-2 (1H)-one ([11C] 17), 8-methoxy-1-[11C] methyl-4-methylquinolin-2 (1H)- ...