Synthesis of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro [5.5] undec-1-enes

N Cohen, BL Banner, JF Blount, G Weber…

Index: Cohen,N. et al. Journal of Organic Chemistry, 1974 , vol. 39, p. 1824 - 1833

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Citation Number: 9

Abstract

... These data are summarized in Tables I and 11. By integration of the N-acetyl peak areas due to 17c and 18c in the crude mix- ture, it was possible to estimate that the ratio of parent amines was approximately 3: 1. It would be expected that the epimer in which the CS proton encounters a 1,3-diaxial interaction with the nitro- Page 3. 1826 J. Org. Chem., Vol. ... 21 22 Et, ,Et 23 1 H 24 ... Chem., Vol. 39, No. 13, 1974 Cohen, Banner, Blount, Weber, Tsai, and Saucy ...