Synthesis and structure-activity relationships of soluble 7-substituted 3-(3, 5-dimethoxyphenyl)-1, 6-naphthyridin-2-amines and related ureas as dual inhibitors of the …

AM Thompson, AM Delaney, JM Hamby…

Index: Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A. Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653

Full Text: HTML

Citation Number: 48

Abstract

7-Substituted 3-aryl-1, 6-naphthyridine-2, 7-diamines and related 2-ureas are inhibitors of fibroblast growth factor receptor-1 (FGFR-1) and vascular endothelial growth factor receptor- 2 (VEGFR-2). 3-(3, 5-Dimethoxyphenyl) and 3-phenyl analogues were prepared from 7- acetamido-2-tert-butylureas by alkylation with benzyl ω-iodoalkyl ethers, debenzylation, and amination, followed by selective cleavage of the 7-N-acetamide. 3-(2, 6-Dichlorophenyl) ...