A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs

…, JM Domagala, C Humblet, J Kosinski…

Index: Lunney; Hagen; Domagala; Humblet; Kosinski; Tait; Warmus; Wilson; Ferguson; Hupe; Tummino; Baldwin; Bhat; Liu; Erickson Journal of Medicinal Chemistry, 1994 , vol. 37, # 17 p. 2664 - 2677

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Citation Number: 102

Abstract

Extensive research to identify a combatant of the human immunodeficiency virus (HIV-1) has targeted the HIV-1 protease This macromolecule processes HIV polyproteins to produce structural and functional proteins, including the protease itself, and has shown to be essential for viral replicati~ n.~-~ HIV-1 protease, a member of the aspartic protease family of enzyme^,^'^ is active as a homodimer. Each monomer consists of 99 amino acids and ...

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