Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases

…, CM Wang, H Cao, L Li, XJ Guo, F Wang…

Index: Wang, Yue; Guan, Xin-Lei; Wu, Peng-Fei; Wang, Can-Ming; Cao, Hui; Li, Lei; Guo, Xiao-Juan; Wang, Fang; Xie, Na; Jiang, Feng-Chao; Chen, Jian-Guo Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3588 - 3592

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Citation Number: 26

Abstract

Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed a synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, and less hepatotoxicity, emerging as promising molecules for the therapy of age-related neurodegenerative diseases.