Tetrahedron Letters

Synthesis of 2, 3-dicarbonylated pyrroles and furans via the three-component Hantzsch reaction

TA Moss, T Nowak

Index: Moss, Thomas A.; Nowak, Thorsten Tetrahedron Letters, 2012 , vol. 53, # 24 p. 3056 - 3060

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Citation Number: 24

Abstract

Pyrroles containing a 2, 3-dicarbonyl substitution pattern are synthesized in one step via a three-component Hantzsch procedure. The normally difficult-to-access substrates are readily obtained in short reaction times and in moderate to good yields, giving pharmaceutically attractive products containing multiple handles for further elaboration.