Isoindolone formation via intramolecular Diels–Alder reaction

…, K Leslie, S Lyons, B McKeever-Abbas…

Index: Ball, Matthew; Boyd, Alistair; Churchill, Gwydion; Cuthbert, Murray; Drew, Mark; Fielding, Mark; Ford, Gair; Frodsham, Lianne; Golden, Michael; Leslie, Kevin; Lyons, Sarah; McKeever-Abbas, Ben; Stark, Andrew; Tomlin, Paula; Gottschling, Stephen; Hajar, Abraham; Jiang, Ji-Long; Lo, Josephine; Suchozak, Bob Organic Process Research and Development, 2012 , vol. 16, # 5 p. 741 - 747

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Citation Number: 18

Abstract

The intramolecular Diels–Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1, 5, 7-substituted isoindolone, is reported herein.