Esterolytic antibodies induced to haptens with a 1, 2-amino alcohol functionality

…, O Ersoy, T Tsumuraya, J Lee, AJ Sinskey…

Index: Suga, Hiroaki; Ersoy, Oguz; Tsumuraya, Takeshi; Lee, Jung; Sinskey, Anthony J.; Masamune, Satoru Journal of the American Chemical Society, 1994 , vol. 116, # 2 p. 487 - 494

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Citation Number: 35

Abstract

Abstract: Three structurally related haptens 1-3 were designed and synthesized with the goal of generating antibodies for the hydrolysis of ester 4a and amide 4b. These haptens contain a 1, 2-amino alcohol functionality which replaces the ester/amide moiety of the substrates. A number of catalytic antibodies were generated, and the Michaelis-Menten kinetics constants of three representative catalytic antibodies induced to each of haptens 1 ...