Synthetic Communications

Use of Magnesium (Turnings) as a Powerful Catalyst for the O-Acylative Cleavage of Tetrahydrofuran

MA Pasha, K Manjula

Index: Pasha; Manjula, Krishnappa Synthetic Communications, 2011 , vol. 41, # 15 p. 2309 - 2314

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Citation Number: 2

Abstract

The cleavage of tetrahydrofuran (THF) with acyl chlorides to give 4-chlorobutyl esters is a useful reaction, particularly in the synthesis of natural products and polyfunctional molecules where a four-carbon chain is required to be added. [ 1 1. (a) Bhatt , MV ; Kulkarni , SU Cleavage of ethers